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Study Questions 1. Metalloproteases have been suspected of playing a role in the ingression of epithelial cells through a basal lamina to invade and become part of a mesenchyme. (a) Name some instances in amniote development where such an ingression occurs. (b) Devise an experimental strategy to test whether metalloproteases affect any processes in part a.
2. What is haptotaxis, and how would you evaluate its role in the migration of the mesonephric duct?
3. The pancreatic epithelium of an 11-day mouse embryo is just beginning to bulge into the surrounding mesenchyme. When you isolate a pancreatic anlage and remove its mesenchyme, the isolated epithelium can be cultured with the following tissues, giving the different results shown below
ANSWER 4. FGF2, FGF4, FGF8, and FGF10 will all stimulate limb outgrowth. How can you experimentally evaluate which of these, if any, might be involved in the initial outgrowth of the limb bud and establishment of the AER?
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